Course Outline

MBT355 Bioinformatics

Course Coordinator:Renfu Shao (rshao@usc.edu.au) School:School of Science, Technology and Engineering

2024Semester 1

UniSC Sunshine Coast

UniSC Moreton Bay

Blended learning Most of your course is on campus but you may be able to do some components of this course online.

Please go to usc.edu.au for up to date information on the
teaching sessions and campuses where this course is usually offered.

What is this course about?

Description

This course will introduce you the principles and key concepts of bioinformatics and will start with basics about DNA, RNA and protein, then progress to databases, sequence alignments, evolutionary history reconstruction, genome annotation, and analysis of gene and protein expression. Systems biology, linux system and programming will also be introduced. Computer-based labs will provide you hands-on experience with databases and bioinformatics tools, and develop your skills in the analysis of biological data.

How will this course be delivered?

Activity Hours Beginning Week Frequency
Blended learning
Learning materials – The learning materials will introduce you the principles and key concepts of bioinformatics. Your will review the basics about DNA, RNA and protein, then progress to databases, sequence alignments, evolutionary history reconstruction, genome annotation, and analysis of gene and protein expression. Systems biology, linux system and programming will also be introduced. 2hrs Week 1 12 times
Laboratory 1 – Computer-based lab practicals will provide you hands-on experience with databases and bioinformatics tools, and develop your skills in the analysis of biological data. 2hrs Week 1 12 times
Seminar – These seminars will guide students to revise course learning materials and prepare for the end of semester exam. 1hr Week 1 3 times

Course Topics

Bioinformatics, sequence, structure, database, genomics, transcriptomics, systems biology, programming

What level is this course?

300 Level (Graduate)

Demonstrating coherence and breadth or depth of knowledge and skills. Independent application of knowledge and skills in unfamiliar contexts. Meeting professional requirements and AQF descriptors for the degree. May require pre-requisites where discipline specific introductory or developing knowledge or skills is necessary. Normally undertaken in the third or fourth full-time study year of an undergraduate program.

What is the unit value of this course?

12 units

How does this course contribute to my learning?

Course Learning Outcomes On successful completion of this course, you should be able to... Graduate Qualities Completing these tasks successfully will contribute to you becoming...
1 Explain and describe the principles and key concepts of bioinformatics. Knowledgeable
2 Critically analyse how bioinformatics is used to make discoveries in biological sciences. Creative and critical thinker
3 Develop skills in literature review, database search, and the use of bioinformatics tools to address questions in biology. Empowered
4 Demonstrate skills to communicate scientific ideas to a variety of audiences regarding concepts in bioinformatics. Empowered

Am I eligible to enrol in this course?

Refer to the UniSC Glossary of terms for definitions of “pre-requisites, co-requisites and anti-requisites”.

Pre-requisites

LFS252 or SCI212 or BIM202

Co-requisites

Not applicable

Anti-requisites

Not applicable

Specific assumed prior knowledge and skills (where applicable)

Basic knowledge in genetics and molecular biology and basic computer skills

How am I going to be assessed?

Grading Scale

Standard Grading (GRD)

High Distinction (HD), Distinction (DN), Credit (CR), Pass (PS), Fail (FL).

Details of early feedback on progress

Early feedback will be provided in Weeks 1-4 in the practical reports. 

Assessment tasks

Delivery mode Task No. Assessment Product Individual or Group Weighting % What is the duration / length? When should I submit? Where should I submit it?
All 1 Report Individual 35%
150 words
Throughout teaching period (refer to Format) Online Submission
All 2 Essay Individual 30%
2000 words
Week 12 Online Assignment Submission with plagiarism check
All 3 Examination - Centrally Scheduled Individual 35%
2 hours
Exam Period Exam Venue
All - Assessment Task 1:Practical reports
Goal:
This task is designed to assist you to develop your conceptual understanding and practical skills in bioinformatics. You will use bioinformatics tools to address questions in biology.
Product: Report
Format:
There are weekly practical activities in this course. Each practical comprises a set of short-answer questions. You are required to submit a report to answer the questions from each practical. Submit each report electronically in the following week after you undertake the practical.
Criteria:
No. Learning Outcome assessed
1
Completeness of all reports
1
2
Explanations and descriptions
2
3
Application of bioinformatics tools
3
All - Assessment Task 2:Essay
Goal:
To develop research and writing skills and in-depth understanding of scientific literature on a chosen bioinformatics tool and its use in biological discoveries.
Product: Essay
Format:
You are required to submit an essay developed from your research concerning a bioinformatics tool of your choice. Search and review the literature published in peer-reviewed journals such as Bioinformatics, Genome Research, Molecular Biology and Evolution, Nucleic Acids Research, etc. Limit your essay to 2,000 words (excluding figures, tables, references and appendixes). Your essay must cover the following four aspects:1. Introduction of your chosen bioinformatics tool. Include information such as who developed the tool, what the tool is for, where the tool was published, how users can access this tool, who used the tool, etc. (20%)2. Principles and rationale of your chosen bioinformatics tool. Explain how the tool is designed (30%)3. Use of the bioinformatics tool in biological research. Explain what questions the bioinformatics tool has been used to address. Provide at least two examples in which the tool has facilitated discoveries. (40%)4. Future improvement of the tool. Offer your opinions and comments how the tool may be improved. (10%) Submit your essay electronically to Canvas - Turnitin before 5 pm, Friday, in Week 12 unless you have won an extension by completing the weekly online quizzes and short-answer questions. You will get 1-day extension for submission if you complete all of the online quizzes, and an additional 1-day extension if you complete all of the online short-answer questions. Furthermore, if your total score from the online quizzes and short-answer questions is 165 or above, you will get an extra 1-day extension.
Criteria:
No. Learning Outcome assessed
1
Description of the chosen bioinformatics tool
1
2
Explanation of the principles and rationale of the tool
2
3
Application of the tool
3
4
Appropriate selection of academic literature.
2
5
Critique of the literature
2
6
Critical analysis of the tool
2
7
Communication and use of references
4
All - Assessment Task 3:End of semester exam
Goal:
 
Product: Examination - Centrally Scheduled
Format:
You will sit a 2-hour exam based on the learning materials given in the course. The exam will be held under official exam conditions in a centralised exam venue. The exam will comprise multiple choice and short-answer questions. Online quizzes and short-answer questions will be provided from each week's learning materials to help you prepare the end of semester exam. You are strongly encouraged to complete all of the online quizzes and short-answer questions.
Criteria:
No. Learning Outcome assessed
1
Knowledge, explanations and descriptions of bioinformatics concepts and principles.
1
2
Critical analysis of how bioinformatics is used to make discoveries in biological sciences.
2
3
Communication of scientific ideas to a variety of audiences regarding concepts in bioinformatics
3

Directed study hours

A 12-unit course will have total of 150 learning hours which will include directed study hours (including online if required), self-directed learning and completion of assessable tasks. Student workload is calculated at 12.5 learning hours per one unit.

Schedule

Period and Topic Activities
Week 1 Course introduction; DNA, RNA and protein
Learning materials, Computer lab practical
Week 2 DNA sequencing technology, data generation and quality assessment
Learning materials, Computer lab practical
Week 3 Molecular biology databases
Learning materials, Computer lab practical
Week 4 Sequence alignment
Learning materials, Computer lab practical
Week 5 Revealing genome features
Learning materials, Computer lab practical
Week 6 Human genome analysis
Learning materials, Computer lab practical
Week 7 Protein secondary structure
Learning materials, Computer lab practical
Week 8 Protein tertiary structures
Learning materials, Computer lab practical
Week 9 Protein - from structure to function
Learning materials, Computer lab practical
Week 10 Gene and protein expression analysis
Learning materials, Computer lab practical
Week 11 Systems biology
Learning materials, Computer lab practical
Week 12 Linux system and programming
Learning materials, Computer lab practical
Week 13 Revision and exam prep
Seminar

What resources do I need to undertake this course?

Please note: Course information, including specific information of recommended readings, learning activities, resources, weekly readings, etc. are available on the course Canvas site– Please log in as soon as possible.

Prescribed text(s) or course reader

Please note that you need to have regular access to the resource(s) listed below. Resources may be required or recommended.

Required? Author Year Title Edition Publisher
Recommended Marketa J. Zvelebil,Marketa J (The Institute of Cancer Research Zvelebil, UK),Marketa Zvelebil,Jeremy O. Baum,Jeremy O.. Baum 2008 Understanding Bioinformatics 1st Garland Science

Specific requirements

Nil

How are risks managed in this course?

Risk assessments have been performed for all studio and laboratory classes and a low level of health and safety risk exists. Some risk concerns may include equipment, instruments, and tools; as well as manual handling items within the laboratory. It is your responsibility to review course material, search online, discuss with lecturers and peers and understand the risks associated with your specific course of study and to familiarise yourself with the University’s general health and safety principles by reviewing the online induction training for students, and following the instructions of the University staff.

What administrative information is relevant to this course?

Assessment: Academic Integrity

Academic integrity is the ethical standard of university participation.  It ensures that students graduate as a result of proving they are competent in their discipline.  This is integral in maintaining the value of academic qualifications. Each industry has expectations and standards of the skills and knowledge within that discipline and these are reflected in assessment.

Academic integrity means that you do not engage in any activity that is considered to be academic fraud; including plagiarism, collusion or outsourcing any part of any assessment item to any other person.  You are expected to be honest and ethical by completing all work yourself and indicating in your work which ideas and information were developed by you and which were taken from others. You cannot provide your assessment work to others. You are also expected to provide evidence of wide and critical reading, usually by using appropriate academic references.

In order to minimise incidents of academic fraud, this course may require that some of its assessment tasks, when submitted to Canvas, are electronically checked through Turnitin.  This software allows for text comparisons to be made between your submitted assessment item and all other work to which Turnitin has access.

Assessment: Additional Requirements

Eligibility for Supplementary Assessment

Your eligibility for supplementary assessment in a course is dependent of the following conditions applying:

The final mark is in the percentage range 47% to 49.4%
The course is graded using the Standard Grading scale
You have not failed an assessment task in the course due to academic misconduct

Assessment: Submission penalties

Late submission of assessment tasks may be penalised at the following maximum rate (the rates are cumulative): 
- 5% (of the assessment task's identified value) per day for the first two days from the date identified as the due date for the assessment task. 
- 10% (of the assessment task's identified value) for the third day 
- 20% (of the assessment task's identified value) for the fourth day and subsequent days up to and including seven days from the date identified as the due date for the assessment task. 
- A result of zero is awarded for an assessment task submitted after seven days from the date identified as the due date for the assessment task. 
Weekdays and weekends are included in the calculation of days late. 
To request an extension you must contact your course coordinator to negotiate an outcome.

SafeUniSC

UniSC is committed to a culture of respect and providing a safe and supportive environment for all members of our community. For immediate assistance on campus contact SafeUniSC by phone: 07 5430 1168 or using the SafeZone app. For general enquires contact the SafeUniSC team by phone 07 5456 3864 or email safe@usc.edu.au.

The SafeUniSC Specialist Service is a Student Wellbeing service that provides free and confidential support to students who may have experienced or observed behaviour that could cause fear, offence or trauma. To contact the service call 07 5430 1226 or email studentwellbeing@usc.edu.au.

Study help

For help with course-specific advice, for example what information to include in your assessment, you should first contact your tutor, then your course coordinator, if needed.

If you require additional assistance, the Learning Advisers are trained professionals who are ready to help you develop a wide range of academic skills. Visit the Learning Advisers web page for more information, or contact Student Central for further assistance: +61 7 5430 2890 or studentcentral@usc.edu.au.

Wellbeing Services

Student Wellbeing provide free and confidential counselling on a wide range of personal, academic, social and psychological matters, to foster positive mental health and wellbeing for your academic success.

To book a confidential appointment go to Student Hub, email studentwellbeing@usc.edu.au or call 07 5430 1226.

AccessAbility Services

Ability Advisers ensure equal access to all aspects of university life. If your studies are affected by a disability, learning disorder mental health issue, injury or illness, or you are a primary carer for someone with a disability or who is considered frail and aged, AccessAbility Services can provide access to appropriate reasonable adjustments and practical advice about the support and facilities available to you throughout the University.

To book a confidential appointment go to Student Hub, email AccessAbility@usc.edu.au or call 07 5430 2890.

Links to relevant University policy and procedures

For more information on Academic Learning & Teaching categories including:

  • Assessment: Courses and Coursework Programs
  • Review of Assessment and Final Grades
  • Supplementary Assessment
  • Central Examinations
  • Deferred Examinations
  • Student Conduct
  • Students with a Disability

For more information, visit https://www.usc.edu.au/explore/policies-and-procedures#academic-learning-and-teaching

Student Charter

UniSC is committed to excellence in teaching, research and engagement in an environment that is inclusive, inspiring, safe and respectful. The Student Charter sets out what students can expect from the University, and what in turn is expected of students, to achieve these outcomes.

General Enquiries

  • In person:
    • UniSC Sunshine Coast - Student Central, Ground Floor, Building C, 90 Sippy Downs Drive, Sippy Downs
    • UniSC Moreton Bay - Service Centre, Ground Floor, Foundation Building, Gympie Road, Petrie
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